Specifically, IRS1 and PHGDH emerge as the DE RNAs causative of nutritional and metabolic associated diseases, and these are two regulators extremely relevant and characterized in diabetes, lipidemia, obesity (IRS1), and phosphoglycerate dehydrogenase deficiency (PHGDH). The gene discussed is PHGDH; the disease is 3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form.