Specifically, IRS1 and PHGDH emerge as the DE RNAs causative of nutritional and metabolic associated diseases, as they are extremely relevant and characterized in diabetes, lipidemia, obesity (IRS1), and phosphoglycerate dehydrogenase deficiency (PHGDH) (Figure 5b). This evidence concerns the gene PHGDH and 3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form.