Although PRDXs are largely distributed in seminal plasma as well as in all subcellular sperm compartments [53], spermatozoa from infertile men exhibit lower amounts of PRDX1 and PRDX6 with a relatively high degree of thiol oxidation [54] which inhibits PRDX activities [50,51,53,55]. This evidence concerns the gene PRDX6 and Infertility.