For example, the lncRNAs lnc273–31 and lnc273–34 are expressed at higher levels in CRCs harboring the hotspot p53 mutations R273H compared to CRCs with wild-type p53 and are associated with cancer stem cell self-renewal, epithelial-to-mesenchymal transition, invasion, and chemoresistance [105]. Here, TP53 is linked to cancer.