Two additional ncRNAs were also shown to affect p53 levels: the lncRNA CACNA1G-AS1, which decreases p53 levels, is more highly expressed in CRC tissues than in adjacent normal tissue, whereas the circular RNA, circZNF609, which enhances p53 levels, shows decreased expression in CRC compared with adjacent normal tissue [126,127]. The gene discussed is CACNA1G; the disease is colorectal carcinoma.