Interaction of mutant p53 with NF-Y also induces ephrin-B2 expression, thereby enhancing JNK/c-JUN, SRC/FAK, and SRC/ERK signaling, resulting in enhanced chemoresistance, cancer cell proliferation, and epithelial-to-mesenchymal transition of CRC cells [89]. This evidence concerns the gene TP53 and colorectal carcinoma.