In order to verify the usefulness of SP-D as a marker for evaluating the pulmonary toxicity of nanomaterials, it is important to examine the kinetics of SP-D in lung inflammation caused by nanomaterials, but there are no reports focusing on the kinetics of SP-D in exposure to nanomaterials, and there is not enough data to examine SP-D as a useful marker for evaluating their pulmonary toxicity. This evidence concerns the gene SFTPD and inflammatory response.