Therefore, in the present study, in order to clarify the relationship between lung inflammation caused by nanomaterials and SP-D kinetics, we measured SP-D in BALF, lung tissue and blood samples obtained from intratracheal instillation of nanomaterials with different pulmonary toxicities in rats and analyzed the relationship between SP-D and inflammatory markers in lung inflammation caused by nanomaterials. The gene discussed is SFTPD; the disease is inflammation.