S100A8 and Peptic ulcer: For example, H. pylori strains are more pathogenic in the presence of the cagA gene than in its absence [3], which might explain the diverse symptoms and disease associated with H. pylori. Although most patients are asymptomatic, approximately 10% develop peptic ulcers, 1–3% develop gastric cancer (GC), and 0.1% develop mucosa-associated lymphoid tissue (MALT) lymphoma [4].