SERPINA1 and Friedreich ataxia: For EM we analyzed duodenal samples from 2 patients with functional dyspepsia (one of them shown in Figures S1a–c and S4c,f) and liver samples from one patient with Friedreich’s ataxia (shown in respective text figures), from one patient with alpha-1 antitrypsin deficiency (not shown), and from a healthy donor liver.