Notch signaling is a short intercellular communication system studied in neoplasms as a therapeutic target, but it is becoming a new key to the maintenance of vascular homeostasis in atherosclerosis; according to the “traction force” theory, Notch signaling is activated when the MindBomb E3 ubiquitin protein ligase 1 (MIB1) modifies the Notch ligands, allowing the ligand to endocytosis and generating the mechanical force needed to expose the second Notch receptor cleavage site [43]. This evidence concerns the gene MIB1 and atherosclerosis.