Several structural changes and interaction with Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), Estrogen Receptor- (ER-) alpha, ERG Protein-coupled (GPER), Human Epidermal growth factor Receptor 2 (HER-2 also known as ErbB2) and Vascular Endothelial Growth Factor Receptors (VEGFR) increase complexity of these signaling pathways that influence atherosclerosis [43]. The gene discussed is GPER1; the disease is atherosclerosis.