IL6 and Alzheimer disease: Ma et al. [77] also demonstrated that IL-1β and IL-6 hippocampal and pre-frontal cortex content were markedly reduced with RSV supplementation (25 mg/kg/d for 5 weeks) in a concurrent model of T2D and AD (Wistar rats, streptozotocin IP and Aβ hippocampal injections, respectively) which also showed improvements in cognitive function.