SIRT1 and brain injury: A growing body of literature also suggests that SIRT1 plays a major role in facilitating RSV’s anti-inflammatory and anti-oxidative activity through interacting with downstream target proteins [85]: Zou et al. [86] showed that RSV-mediated SIRT1 activity reduced the content of pro-inflammatory cytokines IL-1β and IL-18 and upregulated the antioxidant content of SOD and GSH (traumatic brain injury Sprague–Dawley rats.