TNF and type 2 diabetes mellitus: To highlight this idea of a balanced activation of pathways such as SIRT1 or AMPK, Palomera et al. [142] showed that aged mice (24 month) did not respond to 160 mg/kg RSV following an inflammatory lipopolysaccharide challenge (saw no reductions in TLR4, IL-6, or TNF-α), lending credence to the idea that mismanagement of cellular stressors will impair the cellular ability to deal with metabolic stressors such as T2D, obesity, or neuroinflammation.