Along those same lines, Ma et al. [77] showed in a diabetic AD model (8–10 mo Wistar rats; diabetes conferred via streptozotocin IP) that orally ingested RSV daily (25 mg/kg; 5 weeks) is capable of inducing SIRT1 activation and lowering Il-6 content in both the hippocampus and pre-frontal cortex. Here, IL6 is linked to Alzheimer disease.