GFAP and Alzheimer disease: To confirm that the effects of RSV extend to the brain, Broderick et al. [75] has shown that RSV supplementation in a transgenic AD mouse model (3 × Tg-AD mice; 4 g/kg/day for 5 months) had a marked reduction in pro-inflammatory markers (NF-κB, PARP, GFAP) that were seen with controls.