Pathological events leading to tumorigeneses and tumor maintenance in most cancers including CaCx involve the activation of Wnt/b-catenin, phosphatidylinositol-3 kinase (PI3K)/AKT, epidermal grow factor receptor (EGFR)/vascular endothelial growth factor receptor (VEGFR), Ras/Raf/MEK/ERK, and the deactivation of cellular apoptotic pathways. This evidence concerns the gene MAPK1 and cancer.