Furthermore, overexpression of AQP9 is reported to suppress the levels of GSK3β, cyclin D1, and β-catenin in hepatocellular carcinoma cells, enhancing cell apoptosis and inhibiting tumor growth and metastasis formation both in in vitro and in in vivo studies [66], while AQP5 enriches for cancer-driving stem cells in Lgr5+ intestinal cells, the significant sources of cancer following Wnt pathway hyper-activation in mice distal stomach [67]. This evidence concerns the gene LGR5 and cancer.