For example, while cIap1K14.cre/K14.creXiap−/− mice develop a spongiotic dermatitis with psoriasis-like features affecting the ears and face from around 10 weeks of age, cIap1K14.cre/K14.crecIap2−/− mice become moribund at postpartum day 10 due to widespread dermatoses that, like the Sharpincpdm/cpdm mice, are prevented by Ripk1 heterozygosity [139]. The gene discussed is RIPK1; the disease is skin disorder.