Interestingly, the presence of necrotic lesions in CD patients [202,208], combined with the fact that elevated pRIPK1, pRIPK3, and pMLKL levels in the terminal ileum and colon correlate with severe disease in both CD and UC patients [209,210,211,212], indicates that RIPK1-dependent necroptosis may contribute to pathology in human IBD. The gene discussed is RIPK1; the disease is inflammatory bowel disease.