Intriguingly, a further study showed that conditional deletion of caspase-8 in dendritic cells (Caspase-8CD11c.cre/+) exacerbated arthritis, whilst, conversely, myeloid cell-specific caspase-8 loss (Caspase-8LysM.cre/cre) enhanced disease resolution. This evidence concerns the gene CASP8 and Arthritis.