HMGA1 and metabolic dysfunction-associated steatohepatitis: In addition, the silencing of miR-122 in another hepatocyte model HepG2 cells produces an expression pattern of key hepatic lipogenic genes similar to human NASH, including the mature Sterol Regulatory Element-Binding Transcription Factor isoform 1c and 2 (SREBP-1c and SREBP2) and their downstream targets Fatty Acid Synthase (FAS) and 3-Hydroxy-3-Methyl-Glutaryl-CoA reductase (HMGR) [46].