INS and Insulin resistance: The iAUC indicates that HFD mice developed insulin resistance (7529 ± 1469 mg/dL) compared to SD mice (13,804 ± 1816 mg/dL) and, interestingly, HFD+E administration was able to induce a partial rescue of insulin sensitivity in mice (10,138 ± 1620 mg/dL) (Figure 2b).