GLI3 and osteosarcoma: The expression of the other four master regulators (ARNT2, GLI3, PBX3, and CREB3L1) had no significant difference among the samples, except by CREB3L1 gene which was highly expressed in osteosarcoma samples (Pairwise Wilcox test with Bonferroni correction, p-value < 0.01).