Loss of the alpha-dystroglycan-laminin interaction, due to defective glycosylation of alpha-dystroglycan, underlies a group of congenital muscular dystrophies often associated with brain malformations, referred to as dystroglycanopathies, where NBD is reported [31]. The gene discussed is DAG1; the disease is neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.