A recently commercialized product—the Proclarix—incorporating THBS1, CTSD, tPSA and % of fPSA, combined with patient age, yielded a significantly better diagnostic accuracy compared to either PSA or % of fPSA alone in discriminating clinically significant from no or insignificant prostate cancer [43,44]. The gene discussed is KLK3; the disease is Familial prostate cancer.