TNF and Familial prostate cancer: Several immune and inflammatory genes harbouring single nucleotide polymorphisms (SNPs) associated with prostate cancer risk were identified, including pattern recognition receptors (macrophage scavenger receptor 1 or MSR1, TLR1, TLR4, TLR5, TLR6, and TLR10) [117,118,119,120]; antiviral genes (ribonuclease L or RNASEL) [121,122]; cytokines (macrophage inhibitory cytokine 1 or MIC1, IL-8, TNF-α, and IL-1 receptor antagonist or IL1RN) [123,124]; and the proinflammatory gene cyclooxygenase 2 (COX-2) [125].