Granulocyte colony-stimulating factor (G-CSF), IL-1β, or tumour necrosis factor (TNF) secreted by tumour cells extend the lifespan of neutrophils and attract them to the tumour microenvironment, where they become immunosuppressive tumour-associated neutrophils, which stimulate proliferation of tumour cells and angiogenesis [105]. This evidence concerns the gene CSF3 and neoplasm.