Activation of the innate immune system implies upregulation of major histocompatibility (MHC) class I and II molecules on the surface of nucleated cells and antigen presenting cells (APCs) like macrophages, dendritic cells (DCs) and B lymphocytes and presentation of tumour associated antigens on their MHC molecules to naive T lymphocytes [102]. Here, HLA-C is linked to neoplasm.