Specifically, miR-126 independently suppressed the sequential recruitment of mesenchymal stem cells and inflammatory monocytes, the precursors of tumor associated macrophages, into the tumor stroma by targeting stroma cell-derived factor-1 alpha (SDF1a) or the chemokine (C-C motif) ligand 2 (CCL2) in cancer cells [56]. The gene discussed is CXCL12; the disease is cancer.