ADM and acute respiratory distress syndrome: Bio-ADM levels increased with the severity of ARDS (p < 0.001): bio-ADM increased from a median (IQR) of 28.3 {19.9–28.4} pg/mL for patients without ARDS to 39.0 {29.2–54.5} pg/mL for patients with mild ARDS, to 48.1 {26.9–79.8} pg/mL for patients with moderate ARDS and to 101.9 {67.0–201.1} pg/mL for patients with severe ARDS (Figure 1).