Based on the treatment’s anti-inflammatory effects in synovial tissues, significant reduction in TLR4, and inhibitory actions on RA progression (as it is also described via the evaluation of clinical scores), the study concludes that paeonol can be a potential agent against RA, underling that the potential mechanism of action might be based on the attenuation TLR4-NF-κB activation [115]. The gene discussed is TLR4; the disease is rheumatoid arthritis.