In relation to this, it is also reported that the treatment decreased the ratio of Th1/Th2 cells and improved IκB expression, but suppressed p-p65 level in CIA mice which, overall, led to the interpretation that the alleviated progression of arthritis by the treatment might be related to the regulation of Th1/Th2 balance and inactivation of the NF-κB pathway [109]. This evidence concerns the gene NFKB1 and Arthritis.