TNF and rheumatoid arthritis: However, a significant finding of this study is also that sulforaphane attenuated the production of IL-6, TNF-α, IL-17, and pathologic IgG in human peripheral blood mononuclear cytokines (PBMCs) (pro- to anti-inflammatory cytokines produced by mitogen-stimulated PBMCs has been also studied as biomarkers of RA progression) [118,124].