A study demonstrated that the upregulation of Sirt1 by resveratrol suppressed the Bradykinin-induced COX-2/PGE2 production through inhibiting the interactions of AP-1 and NF-κB with COX-2 promoter in RA synovial fibroblasts, while resveratrol also inhibited the phosphorylation and acetylation of p65, and reduced the binding to the COX-2 promoter, thereby attenuating COX-2 expression [87]. This evidence concerns the gene KNG1 and rheumatoid arthritis.