In order to delineate how DYRK1A downregulates SOX2 expression, we analysed our proteomic and phosphoproteomic data obtained from U251 glioblastoma cells infected with doxycycline (DOX)-inducible DYRK1A shRNA (sh-DYRK1A U251) or treated with DYRK1A inhibitor ALGERNON [17]. Here, SOX2 is linked to glioblastoma.