PRSS1 and Lynch syndrome: CDKN2A mutations have been linked with familial atypical multiple-mole melanoma [144,145], STK11 mutations to Peutz–Jeghers syndrome [146], PRSS1 mutation to patients with hereditary pancreatitis [147,148,149,150], and MLH1, MSH2, MSH6 and PMS2 mutations are all associated with Lynch syndrome [151].