NOTCH1 and renal fibrosis: Lyso-Gb3 has been shown to induce, in cultured human podocytes, overexpression of TGF-β1 and CD74 [42], which are involved in the regulation of inflammation and development of renal fibrosis [51,52], overexpression of the ECM proteins fibronectin and type IV collagen [42], and increased Notch1 signaling, a pathway involved in the induction of podocyte injury and renal fibrosis, as well as overexpression of MCP-1, RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) and fibronectin.