Moreover, there is evidence that sleep disorders may be associated with cardiovascular diseases and cardiovascular risk factors, such as hypertension and elevated resting heart rate in the general population [24], and that cardiovascular medications such as beta adrenergic blocking agents, ACE inhibitors, calcium channel antagonists may negatively affect sleep quality in individuals with other comorbidities, especially those with sleep disorders breathing [25]. This evidence concerns the gene ACE and cardiovascular disorder.