TNF and colorectal carcinoma: Moreover, in a murine model of CRC (CT26), CD103-expressing effector TA-Tregs express higher levels of TNFR2, as observed in human tumors, and the blockade of the TNFR2/TNF-α axis with a sTNFR2-Fc chimera efficiently inhibits their TNF-α-induced expansion in vitro [187].