Moreover, in murine tumor models, targeting CCR8 with a CCR8-neutralizing mAb (mIgG2b) induces a protective immunity and enhances the vaccine-induced response to CRC in CT26 and MC38 subcutaneous tumor models through the inhibition of CCR8+ Treg recruitment without impacting the peripheral FOXP3+ Treg subsets [96]. Here, FOXP3 is linked to colorectal carcinoma.