CCR2 and colorectal carcinoma: Even if the CCR2 axis is dominantly involved in TAM and MDSC recruitment at tumor sites, it also contributes to Treg recruitment in the TME, although, in human tumors, the expression of CCR2 on T cells does not appear selective for TA-Tregs, at least in NSCLC [44] and CRC [65] (Figure 2).