Although reports suggest that the microbiome is altered in obesity [61] and that the luminal concentration of by-products of bacterial fermentation, i.e., SCFAs, may be altered [62], we report no change in the mRNA expression of the SCFA receptors GPR43, GPR41 or GPR109a. The gene discussed is FFAR2; the disease is obesity due to melanocortin 4 receptor deficiency.