Instead, nuclear aggregation of TDP-43 was frequently detected in cells coexpressing DCTN1G59S and TDP-43 (Figure 5D and Figure S2E), suggesting that TDP-43 (micro)aggregation at neuropathologically undetectable levels, especially within the nucleus, may be present in HMN7B patients. Here, TARDBP is linked to neuronopathy, distal hereditary motor, type 7B.