TARDBP and neurodegenerative disease: On the other hand, Perry disease is an autosomal dominant, fatal neurodegenerative disease characterized clinically by early-onset parkinsonism, depression/apathy, weight loss and central hypoventilation; and pathologically by degeneration of substantia nigral dopaminergic neurons and TDP-43 proteinopathy [45,46,47,48,49,50].