DCTN1 and neuronopathy, distal hereditary motor, type 7B: It remains unsolved how closely apposed missense mutations within the DCTN1 CAP-Gly domain (Figure 1A) cause two distinct types of diseases with completely different symptoms: Perry disease that accompanies TDP-43 proteinopathy and HMN7B that does not accompany TDP-43 proteinopathy [50].