The SOD1 rs2234694 [A/C] is located at the third exon/intron splicing site, the SOD2 rs4880 [A/G] has been found to impact the “mitochondrial targeting peptide; MTP” domain of the enzyme [32], and the SOD3 rs2536512 [A/G] results in alanine substituted by threonine; collectively, they have been associated previously with obesity risk [29,33]. This evidence concerns the gene SOD2 and obesity due to melanocortin 4 receptor deficiency.