However, given the essential roles that the encoded enzyme plays in the reduction in hydroperoxides of non-esterified polyunsaturated fatty acids [35], as well as regulation of “insulin sensitivity” and “obesity-induced insulin resistance” [80,81], it is not surprising that it is one of the obesity-related susceptibility SNPs that deserves work replication in other populations to confirm this finding. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.