The use of CG-DES in topical formulations was proved by our research group to greatly increase the transdermal permeation of curcumin (which will enable advances in the application of this biomacromolecule to treat chronic skin diseases), insulin (which will enable the development of non-invasive systems for insulin administration), and bacteriophage particles (enabling the treatment of localized bacterial infections in the deeper layers of the skin). This evidence concerns the gene INS and bacterial infectious disease.