LRRN4 and Crohn disease: Interestingly, the expression of several mesothelial genes in mesenteric fat-derived ASCs from patients with Crohn’s disease showed a clear upregulation with respect to equivalent lean VAT-derived ASCs, namely LRRN4, carbonic anhydrase 2 (CA2), MSLN, and KRT8 (Figure 4), with a trend for greater expression for others including CDH1, KTR7, WT1, and THBD. No differences were observed for the expression of mesenchymal markers in obese, morbid obese, and Crohn’s disease VAT and VAT-derived ASCs with respect to equivalent lean-derived samples (Supplementary Figure S3).