Another study [24] investigated the role of ApoE polymorphism in modulating the progression of liver fibrosis in HCV-gt1b patients with normal transaminases and found that the E2 and E4 alleles were associated with less severe fibrosis in chronic HCV infection, unlike the E3 allele, which is considered as a risk factor for rapid fibrosis progression [24]. This evidence concerns the gene APOE and Hepatic fibrosis.