In a mouse chronic kidney disease model, intravenously injected human Muse cells homed to the site of damage and spontaneously differentiated into podocytes (positive for WT-1 and podocin), mesangial cells (positive for megsin), and endothelial cells (positive for CD31 and von Willebrand factor), which are components of the glomerulus, without fusion and improved creatinine clearance, urine protein, and plasma creatinine [35]. Here, WT1 is linked to chronic kidney disease.