MAPT and Alzheimer disease: DAM-like cells or MGnD phenotypes have been characterized in the Aβ-producing 5xFAD and APP/PSΔE9 AD mouse models [51,171,172], the Tau-producing P301S AD mouse model [173], mouse models of amyotrophic lateral sclerosis [51,52,174] and mouse models for multiple sclerosis [52].