Added to the declined collagen biosynthesis, the enhanced MMP activity and the plasminogen activator inhibitor-1 (PA-1), FGF and syndecan-1 overexpression reported previously to characterize senescent breast stromal fibroblasts [19,80,81,82], decorin down-regulation comes to reinforce the already tumor-promoting phenotype of these cells. Here, PAGR1 is linked to neoplasm.