We found that inhibition of FGF and VEGF reversed the MDA-MB-231 conditioned medium-induced decorin down-regulation in young and senescent human breast fibroblasts, indicating that FGF is released—amongst other soluble factors—by MDA-MB-231 breast cancer cells and can act in a paracrine manner on breast stromal cells directly and/or indirectly by enhancing stromal VEGF overexpression, ultimately inducing the decrease in their decorin expression. This evidence concerns the gene DCN and breast cancer.