DAMPs are detected by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), receptor for advanced glycation end products (RAGE), and c-GAS (a cytosolic PRRs), which activate downstream signaling pathways to induce production of cytokines that drives the progression of NAFLD [77,78,79]. The gene discussed is AGER; the disease is metabolic dysfunction-associated steatotic liver disease.