NF-κB is often upregulated in HNSCC [51] and promotes the upregulation of downstream anti-apoptotic factors, such as BCL2 [52], STAT3 [46], TNF-α [32,53], and various others cytokines related to oncogenesis, like IL6 and IL1β [35,36]. Here, IL6 is linked to head and neck squamous cell carcinoma.