Interestingly, most of the genes were actively transcribed in GC from human antral and preovulatory follicles (Figure 5) as PTPN2 and PTP1B, suggesting this way that previously observed changes in gene expression in CC in early obesity, driven by increased leptin activity, could be seemingly important for GC from preantral and antral follicles. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.