LEP and obesity due to melanocortin 4 receptor deficiency: In addition to increased ovarian ObRb activation and altered leptin signaling, deleterious effects of systemic hyperleptinemia during obesity can also result from local overexpression of mediators of leptin resistance, such as SOCS3. As a result, leptin’s prominent role as suppressor of follicular pool activation can be affected in obese mothers, with consequent POF.