The proteins whose expression were altered the most significantly (p < 0.01), along with the increase in tumor size, are listed in Figure 1A. Among these differentially expressed proteins, many proteins have been demonstrated to be involved in glycometabolism, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH) [34] and phosphoglycerate kinase 1 (PGK1) [35], lipid metabolism such as apolipoprotein A4 (APOA4) [36] and protein synthesis or degradation such as plasminogen protein (PLG) [37] in cancer cells. The gene discussed is PLG; the disease is cancer.