CAD and hepatocellular carcinoma: Strikingly, we observed large changes in the metabolites associated with pyrimidine synthesis (UDP sugars and uridine), which are in line with the recent proteogenomic analysis of HCC [12] and the upregulation of CAD protein (CAD), dihydroorotate dehydrogenase (DHODH), uridine 5’-monophosphate synthase (UMPS), CTP synthase 2 (CTPS2) and nucleoside diphosphate kinase A (NME1).