Another group discovered that AML subjects with t (8;12) translocation presented the MST2-ETV6 fusion gene, which is a potential oncogene [186], while in acute lymphoblastic leukemia (ALL) subjects presenting t(12;21) chromosome translocation, an essential element of the Hippo system called KIBBRA was reported to be greatly methylated and could be the more relevant underlying leukemogenesis factor in this type of leukemia [187]. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.