Moreover, the action of YAP/TAZ induces the appearance of chemo-resistant cancer cells and determines a defense against programmed cell death by increasing the production of antiapoptotic genes of the BCL-2 and IAP family, AXL receptor tyrosine kinase, connective tissue growth factor (CTGF), and cysteine-rich angiogenic inducer 61 (CYR61) [10,74,75,76,77]. This evidence concerns the gene CCN2 and cancer.