During the last two decades, several studies have shown that patient brain natriuretic peptide levels on admission (BNP) were elevated in many acute central nervous system (CNS) diseases, including stroke [4,5,6], hypertensive intracerebral hemorrhage (ICH) [7], aneurysmal subarachnoid hemorrhage (aSAH) [7,8,9,10,11] and traumatic brain injury (TBI) [12,13,14]. This evidence concerns the gene NPPB and Stroke.