NET formation participates in many forms of vascular thrombosis ranging from deep venous thrombosis to acute coronary syndromes, and likely some of the thrombotic complications of SARS-CoV-2 infection, including those that affect the cardiovascular system.12 A monoclonal antibody that neutralizes IL-1α can mitigate early atherosclerosis in hypercholesterolemic mice and can reduce experimental stroke [57,58]. This evidence concerns the gene IL1A and atherosclerosis.