Despite the small number of samples in each of the compared groups (on average, 10 samples), which is a limitation of this study, the strength of the present study is the identification of key pairs “miRNA-target gene”, namely miR-30c-5p/VIM, miR-28-3p/VIM, miR-1-3p/ANXA2, miR-30c-5p/FBN1; miR-15b-5p/MYL6, miR-185-3p/FLNA, miR-30c-5p/YWHAZ and miR-654-3p/FGA, able to differentiate PE, IUGR and SGA by expression level in the placental bed. This evidence concerns the gene ANXA2 and fetal growth restriction.