It is underlined that vascular lesions in placenta of IUGR pregnancies are often associated with chronic inflammatory processes, which is supported by the Metascape enrichment analysis data on the involvement of ANXA2/VIM/YWHAZ in signaling by interleukines, suggesting that more than one mechanism is involved in the development of IUGR. The gene discussed is YWHAZ; the disease is fetal growth restriction.