The knockdown of HOTAIR expression in MM cells triggers a decrease in chemoresistance to drugs such as dexamethasone, and the silencing of MIAT (myocardial infarction associated transcript) and PCAT-1 (prostate cancer associated transcript 1) sensitized MM cells to bortezomib [43,48,49,75,76,83,84]. This evidence concerns the gene PCAT1 and Miyoshi myopathy.