Ueland et al. found that women with GDM had increased circulating concentrations of sCD163 as early as 14–16 weeks gestation and 5 years postpartum, compared with women with uncomplicated pregnancies, independent of BMI and other risk factors, proposing monocyte/macrophage activation as an important early mediator in GDM pathology [77]. Here, CD163 is linked to gestational diabetes.