A similar pattern has been identified in type 2 diabetes mellitus (T2DM), whereby hyperglycaemia and hyperlipidaemia in these patients correlated with an imbalanced pro-inflammatory peripheral B cell profile with an increased percentage of CD19+CD23+ B-2 cells and a decreased percentage of CD19+CD23− B-1 cells [157]. This evidence concerns the gene CD19 and Hyperglycemia.