Norepinephrine can also indirectly enhance EMT (N-cadherin, Vimentin, and Snail) and stemness (Nanog) markers in HCC cells by activating hepatic stellate cells that release the secreted frizzled-related protein 1 (sFRP1), which leads to the activation of Wnt/β-catenin pathway in the tumor cells, thus favoring HCC progression [147]. The gene discussed is VIM; the disease is hepatocellular carcinoma.