Contrarily, in mouse experimental models, exogenous Gal-1 and Gal-9 play anti-inflammatory roles in both AD and allergic contact dermatitis (a Th1/Th17-profile disease), counteracting the inflammation and decreasing the production of IFN-γ and IL-17, but not of Th2 cytokines [7,8]. Here, IFNG is linked to Alzheimer disease.