Altogether, the studies confirm that the Th2-predominant inflammation induces a marked increase in the Gal-9 mRNA and protein levels in AD skins by keratinocytes (epidermis) and inflammatory cells (mast cells and eosinophils in the dermis), an effect abrogated by the inhibition of IL-4/IL-13 signaling. The gene discussed is IL4; the disease is Alzheimer disease.