Regarding AD, epidermal barrier disruption and microbial invasion trigger the production of various keratinocyte-derived cytokines, such as IL-6, TNF-α, and RANTES, which promote the recruitment of inflammatory cells to the skin and activation of T helper (Th)17 cells, which further play an important part in the early stage of this disease [34]. The gene discussed is IL6; the disease is Alzheimer disease.