The pancreatic loop, characteristic of the mammalian PLAG1B, together with the following tyrosine (Y69), form the triplet NPY, a motif present in a pathogenic Escherichia coli effector protein, that binds to the I-BAR domain of a host protein and induces actin polymerization and the formation of the pedestal necessary for the infection process [24,33]. Here, NPY is linked to infection.