Mutations in the LMNA gene are detected in around 5% of patients affected by non-familial dilated cardiomyopathy, 5–10% of patients with familial dilated cardiomyopathy and 33% of cases of familial dilated cardiomyopathy with conduction system defects [104,132]. This evidence concerns the gene LMNA and familial dilated cardiomyopathy.