In particular, a TGFbeta 2 neutralizing antibody elicited reduction of the hypersecreted collagen I and alpha- Smooth Muscle Actin, a marker of profibrotic myofibroblasts, in laminopathic skeletal muscle, while CTGF inhibition in laminopathic mouse myocardium by using an anti-CTGF antibody decreased myocardial fibrosis and improved the left ventricular dysfunction [145,147]. The gene discussed is CCN2; the disease is Myocardial fibrosis.