Mutations in DES (OMIM *125660) or LMNA gene (OMIM *150330) cause striated muscle disorders, including desmin-related myopathy and cardiomyopathy (desminopathy) [40], Emery–Dreifuss Muscular Dystrophy (EDMD2, OMIM # 181350 and EDMD3, OMIM # 616516, due to LMNA mutations), LMNA-related congenital muscular dystrophy (L-CMD, OMIM # 613205), limb-girdle muscular dystrophy type 1B (LGMD1B) and LMNA-linked dilated cardiomyopathy with conduction system defects (CMD1A, OMIM # 115200) [41,42,43,44,45,46]. This evidence concerns the gene DES and Desminopathy.