Of note, mutations in BAG3 gene have been associated with early onset severe MFM with aggregate formation [77] and even mutations in CRYAB gene, encoding for the chaperone alphaB-crystallin, are causative of MFM, pointing to a major role of chaperone proteins in muscular dystrophy and cardiomyopathy pathogenetic pathways (for an updated review see [78]). This evidence concerns the gene CRYAB and muscular dystrophy.