The uncoupler CCCP was used to obtain the maximal dissipation of the ΔΨ and the quantification of replicates was presented in Figure 2H. These results indicated that TR induced caspase-dependent apoptosis and NOXA probably plays a regulatory role in cell death by inhibiting the anti-apoptotic activity of MCL-1 in leukemia Jurkat cells. The gene discussed is MCL1; the disease is leukemia.