It was reported that mice with hepatocyte-specific deletion of MBOAT7 showed spontaneous steatosis with increased hepatic cholesterol ester content, hepatic fibrosis with minimal inflammation after receiving a high-fat, low-methionine, choline-deficient diet, and increased plasma total lysophosphatidylinositol levels, suggesting that Mboat7 deficiency may trigger an inflammation-independent pathway of liver fibrosis [38]. The gene discussed is MBOAT7; the disease is steatosis.