Among mouse models of diet-induced obesity (DIO) with hepatocyte-specific knockout of various genes related to insulin signaling (Table 1), LIrs2KO mice, but not LIrs1KO and LIrs1/2DKO mice, were not protected from hepatic steatosis in spite of the partial impairment of hepatic insulin signaling. This evidence concerns the gene INS and Hepatic steatosis.