TNF and metabolic dysfunction-associated steatohepatitis: TNF-α is also known to play an important role in the development of systemic insulin resistance [74], and overexpression of TNF-α mRNA has been reported in the liver and adipose tissue of NASH patients [75], suggesting that upregulated TNF-α in the adipose tissue might be involved in the progression of NAFLD via increasing systemic insulin resistance, as well as promoting inflammation in various tissues.