TNF-α is also known to play an important role in the development of systemic insulin resistance [74], and overexpression of TNF-α mRNA has been reported in the liver and adipose tissue of NASH patients [75], suggesting that upregulated TNF-α in the adipose tissue might be involved in the progression of NAFLD via increasing systemic insulin resistance, as well as promoting inflammation in various tissues. This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.