Tumour-derived microparticles and exosomes are also a source of various substances, including CD63, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and thrombin, that promote tumour-cell induced platelet aggregation (TCIPA) [17,18] and maintain a hypercoagulable state [8,9,10,11]. The gene discussed is CD63; the disease is neoplasm.