P2RY12 and diabetes mellitus: Different reasons have been proposed to explain the failure of translation of cardioprotective strategies, including presence of comorbidites, such as aging, diabetes, or hypertension, which may alter the efficacy of cardioprotective maneuvers [33], the routine use of different comedications, such as P2Y12 antagonists, which may have protective effects [34], or the lack of uniformity in the method used to quantify infarct size [32].